Dark Light
, , ,

Acetyl L Carnitine 1000mg


Acetyl ester of l-carnitine
Improved bioavailability compared to l-carnitine
Long-chain fatty acid transporter in the mitochondrial matrix for beta-oxidation
1,000mg of acetyl l-carnitine per tablet

170 ден1.020 ден

Clear

Description

Acetyl-L-carnitine (ALCAR or L-acetylcarnitine), is a molecule derived from the acetylation of L-carnitine, both amino acids present in large quantities in cells and tissues. Acetylcarnitine is a fundamental element for the oxidation of fatty acids, a particularly important process as they are the main “nourishment” of the mitochondria, the Energy plants of the cells that make up our complex human body.

This acetylated version of L-carnitine, appears to be more bioavailable with an effect on greater mitochondrial energy, resulting in a more effective transporter of fatty acids, but its field of action comes to significantly affect the nervous system where it exerts an action. trophic and neuroprotective. Acetylcarnitine today is proving to be a real “nootropic” capable of improving cognitive abilities.

Unlike “simple” L-carnitine, it easily crosses the blood brain barrier, increasing the levels of some neurotransmitters that are key to the functioning of memory and cognitive functions. The scientific literature is very interesting about it! Therefore acetyl-L-carnitine exerts a stimulating and energizing action both at the cognitive level and at the level of metabolic energy for the body, in favor of a greater reduction of fatigue even during long-lasting physical activity, with positive implications on the maximal heart rate, with a “welcome” effect on the reduction of post-exercise muscle pain.

 

SCIENTIFIC REFERENCES

Adeva-Andany MM, Calvo-Castro I, Fernández-Fernández C, Donapetry-García C, Pedre-Piñeiro AM. Significance of l-carnitine for human health. IUBMB Life. 2017 Aug; 69 (8): 578-594. doi: 10.1002 / iub.1646. Epub 2017 Jun 26. PMID: 28653367.

 

Maldonado C, Vázquez M, Fagiolino P. Potential Therapeutic Role of Carnitine and Acetylcarnitine in Neurological Disorders. Curr Pharm Des. 2020;26(12):1277-1285. doi: 10.2174/1381612826666200212114038. PMID: 32048954.

 

Traina G. The neurobiology of acetyl-L-carnitine. Front Biosci (Landmark Ed). 2016 Jun 1;21:1314-29. doi: 10.2741/4459. PMID: 27100509.

 

Rebouche CJ. Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism. Ann N Y Acad Sci. 2004 Nov;1033:30-41. doi: 10.1196/annals.1320.003. PMID: 15591001.

 

Rosca MG, Lemieux H, Hoppel CL. Mitochondria in the elderly: Is acetylcarnitine a rejuvenator? Adv Drug Deliv Rev. 2009 Nov 30;61(14):1332-1342. doi: 10.1016/j.addr.2009.06.009. Epub 2009 Aug 29. PMID: 19720100; PMCID: PMC4120470.

 

Bruls YM, de Ligt M, Lindeboom L, Phielix E, Havekes B, Schaart G, Kornips E, Wildberger JE, Hesselink MK, Muoio D, Schrauwen P, Schrauwen-Hinderling VB. Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial. EBioMedicine. 2019 Nov;49:318-330. doi: 10.1016/j.ebiom.2019.10.017. Epub 2019 Oct 31. PMID: 31676389; PMCID: PMC6945245.

 

Notartomaso S, Mascio G, Bernabucci M, Zappulla C, Scarselli P, Cannella M, Imbriglio T, Gradini R, Battaglia G, Bruno V, Nicoletti F. Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain. Mol Pain. 2017 Jan;13:1744806917697009. doi: 10.1177/1744806917697009. PMID: 28326943; PMCID: PMC5407675.

 

Malaguarnera M, Gargante MP, Cristaldi E, Colonna V, Messano M, Koverech A, Neri S, Vacante M, Cammalleri L, Motta M. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue. Arch Gerontol Geriatr. 2008 Mar-Apr; 46 (2): 181-90. doi: 10.1016 / j.archger.2007.03.012. Epub 2007 Jul 20. PMID: 17658628.

SHOPPING CART

close