Acetyl L Carnitine 1000mg

Acetyl-L-carnitine (ALCAR or L-acetylcarnitine), is a molecule derived from the acetylation of L-carnitine, both amino acids present in large quantities in cells and tissues. Acetylcarnitine is a fundamental element for the oxidation of fatty acids, a particularly important process as they are the main “nourishment” of the mitochondria, the Energy plants of the cells that make up our complex human body.

This acetylated version of L-carnitine, appears to be more bioavailable with an effect on greater mitochondrial energy, resulting in a more effective transporter of fatty acids, but its field of action comes to significantly affect the nervous system where it exerts an action. trophic and neuroprotective. Acetylcarnitine today is proving to be a real “nootropic” capable of improving cognitive abilities.

Unlike “simple” L-carnitine, it easily crosses the blood brain barrier, increasing the levels of some neurotransmitters that are key to the functioning of memory and cognitive functions. The scientific literature is very interesting about it! Therefore acetyl-L-carnitine exerts a stimulating and energizing action both at the cognitive level and at the level of metabolic energy for the body, in favor of a greater reduction of fatigue even during long-lasting physical activity, with positive implications on the maximal heart rate, with a “welcome” effect on the reduction of post-exercise muscle pain.

SCIENTIFIC REFERENCES

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Traina G. The neurobiology of acetyl-L-carnitine. Front Biosci (Landmark Ed). 2016 Jun 1;21:1314-29. doi: 10.2741/4459. PMID: 27100509.

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Bruls YM, de Ligt M, Lindeboom L, Phielix E, Havekes B, Schaart G, Kornips E, Wildberger JE, Hesselink MK, Muoio D, Schrauwen P, Schrauwen-Hinderling VB. Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial. EBioMedicine. 2019 Nov;49:318-330. doi: 10.1016/j.ebiom.2019.10.017. Epub 2019 Oct 31. PMID: 31676389; PMCID: PMC6945245.

Notartomaso S, Mascio G, Bernabucci M, Zappulla C, Scarselli P, Cannella M, Imbriglio T, Gradini R, Battaglia G, Bruno V, Nicoletti F. Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain. Mol Pain. 2017 Jan;13:1744806917697009. doi: 10.1177/1744806917697009. PMID: 28326943; PMCID: PMC5407675.

Malaguarnera M, Gargante MP, Cristaldi E, Colonna V, Messano M, Koverech A, Neri S, Vacante M, Cammalleri L, Motta M. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue. Arch Gerontol Geriatr. 2008 Mar-Apr; 46 (2): 181-90. doi: 10.1016 / j.archger.2007.03.012. Epub 2007 Jul 20. PMID: 17658628.